background:
Beta-defensins (also designated BD, and hBD in human) are small cationic peptides with broad-spectrum antimicrobial activity. Produced in mucosal epithelia and neutrophils of several species, Beta-defensins are developmentally regulated. Human b-defensin 2 is locally regulated by inflammation and is the first member of the b-defensin family that is locally inducible by inflammation. The murine homolog of human b-defensin 2, which is called b-defensin 3, is present in the respiratory system and in low levels in the epithelial cells of the intestine and lung. The unique murine b-defensin 2 (Defb2) is not expressed in airways of untreated mice, but is upregulated in the airways by lipopolysaccharide and may contribute to host defense at the mucosal surface of the airways
Function:
Has antibacterial activity.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in the skin and respiratory tract.
Similarity:
Belongs to the beta-defensin family. LAP/TAP subfamily.
Database links:
Entrez Gene: 100289462 Human
Entrez Gene: 1673 Human
Omim: 602215 Human
SwissProt: O15263 Human
Unigene: 105924 Human
Unigene: 721744 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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