background:
Relaxin Receptor 3 is a G protein-coupled receptor that binds Relaxin 3 and influences differentiation and maintenance of the nervous system. Relaxin Receptor 3 shares sequence similarity with somatostatin receptors and angiotensin receptors. It mediates central processing of sensory signals in the rat and is thought to be a modulator of stress responses. Relaxin Receptor 3 is present in the brain, with highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, and low level expression in cerebellum. In peripheral tissues there are high levels in adrenal glands and low levels in pancreas, salivery gland, placenta, mammary gland and testis.
Function:
GPCR SALPR, also known as Relaxin 3 Receptor 1 (RXFP3), is a G-protein coupled receptor that is one of the physiological targets for relaxin 3, an insulin-like hormone. Activation of GPCR SALPR results in phosphorylation of ERK1/2. GPCR SALPR has been implicated in anxiety and obesity. A role for relaxin 3 and GPCR SALPR in reproductive function through the hypothalamic-pituitary-gonadal (HPG) axis has also been described.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed predominantly in brain regions. Highest expression in substantia nigra and pituitary, followed by hippocampus, spinal cord, amygdala, caudate nucleus and corpus callosum, quite low level in cerebellum. In peripheral tissues, relatively high levels in adrenal glands, low levels in pancreas, salivary gland, placenta, mammary gland and testis.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:
Entrez Gene: 51289 Human
Entrez Gene: 239336 Mouse
Entrez Gene: 29967 Rat
Omim: 609445 Human
SwissProt: Q9NSD7 Human
SwissProt: Q8BGE9 Mouse
Unigene: 170146 Human
Unigene: 209312 Mouse
Unigene: 127658 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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