background:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal (Synaptogyrin-1 and -3) and one ubiquitous (Synaptogyrin-2) isoform. Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as cellugyrin, has a tyrosine phosphorylated SLCterminal cytoplasmic tail and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta.
Subcellular Location:
Membrane; Multi-pass membrane protein. Cytoplasmic vesicle (By similarity).
Tissue Specificity:
Ubiquitous; low expression in brain.
Similarity:
Belongs to the synaptogyrin family.
Contains 1 MARVEL domain.
Database links:
UniProtKB/Swiss-Prot: O43760.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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