background:
The synaptogyrin family of proteins are integral membrane proteins containing four transmembrane regions. Synaptogyrins are tyrosine-phosphorylated proteins with two neuronal isoforms (Synaptogyrin-1 and -3) and one ubiquitous isoform (Synaptogyrin-2). Synaptophysin and synaptogyrin represent the major constituents of synaptic vesicles. Synaptogyrin-1 is associated with presynaptic vesicles in neuronal cells. Synaptogyrin-2, also known as cellugyrin, has a tyrosine phosphorylated SLCterminal cytoplasmic tail and is involved in the regulation of membrane traffic in non-neuronal cells. Synaptogyrin-3 is expressed mainly in brain and placenta. Synaptogyrin-4 is a 234 amino acid protein encoded by the SYNGR4 gene.
Function:
Involved in the regulation of short-term and long-term synaptic plasticity.
Subcellular Location:
Membrane; Multi-pass membrane protein. Melanosome. Cell junction, synapse. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:
Belongs to the synaptogyrin family.
Contains 1 MARVEL domain.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
囊泡循环蛋白,Synaptogyrin又称p29，是均一分布于神经系统的突触囊泡蛋白，在神经元及神经内分泌细胞高度表达，它是酪氨酸激酶的一个重要的囊泡相关底物。synaptogyrin为多基因家族编码，异构体的cDNA序列同源性为32%～46％。人的囊泡循环蛋白 cDNA有一阅读框架，编码234个氨基酸，分子量约25,683Da，有四个跨膜域，N端与C端朝向囊泡的胞质面，无糖基化位点，蛋白分子胞浆尾的氨基酸序列与Syp有74％的同源性。
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