Rabbit Anti-Acetoacetyl-CoA synthetase/FITC Conjugated antibody

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Acetoacetyl-CoA synthetase; ACSF1; AACS; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN.

Cat:

SL2283R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human AACS (182-228aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antib

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

75kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

Function:
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development

Subcellular Location:
Cytoplasm, cytosol

Tissue Specificity:
Highly expressed in kidney, heart and brain, but low in liver.

Similarity:
Belongs to the ATP-dependent AMP-binding enzyme family.

Database links:

Entrez Gene: 65985 Human

Entrez Gene: 78894 Mouse

Entrez Gene: 65984 Rat

Omim: 614364 Human

SwissProt: Q86V21 Human

SwissProt: Q9D2R0 Mouse

SwissProt: Q9JMI1 Rat

Unigene: 656073 Human

Unigene: 431573 Mouse

Unigene: 9215 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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