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Rabbit Anti-APOC3/FITC Conjugated antibody
background:
Apolipoprotein SLCIII is a very low density lipoprotein (VLDL) protein. It inhibits lipoprotein lipase and hepatic lipase and it is thought to delay catabolism of triglyceride-rich particles. An increase in apoSLCIII levels induces the development of hypertriglyceridemia.
Function:
Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
Subcellular Location:
Secreted.
Tissue Specificity:
Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
Post-translational modifications:
O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan.
DISEASE:
Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the apolipoprotein C3 family.
Database links:
Entrez Gene: 345 Human
Entrez Gene: 11814 Mouse
Entrez Gene: 24207 Rat
Omim: 107720 Human
SwissProt: P02656 Human
SwissProt: P33622 Mouse
SwissProt: P06759 Rat
Unigene: 73849 Human
Unigene: 390161 Mouse
Unigene: 195323 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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