Home
>
Product
>
Antibody
>
Rabbit Anti-CD30/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function:
Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Subunit:
Interacts with TRAF1, TRAF2, TRAF3 and TRAF5.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:
Detected in thymus and in activated splenocytes.
Similarity:
Contains 3 TNFR-Cys repeats.
Database links:
Entrez Gene: 943 Human
Entrez Gene: 21941 Mouse
Omim: 153243 Human
SwissProt: P28908 Human
Unigene: 1314 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CD30是一种单链糖蛋白,标记活化T和B淋巴细胞,R-S细胞和部分淋巴滤泡间区免疫母细胞。CD30是霍奇金淋巴瘤的一个特异性标记,也是大细胞间变型淋巴瘤的诊断型标志。
|
|