background:
Densin-36 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-36 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-36 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-36, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions.
Function:
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Subunit:
Interacts with CAMKII, CNKSR2 and DLG4 (By similarity). Interacts with CTNND2/Catenin delta-2. Forms a complex with N-cadherin through CTNND2.
Subcellular Location:
Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density.
Tissue Specificity:
Brain-specific. Isoform 3 is ubiquitously expressed.
Similarity:
Belongs to the LAP (LRR and PDZ) protein family.
Contains 17 LRR (leucine-rich) repeats.
Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 57554 Human
Entrez Gene: 242274 Mouse
Entrez Gene: 117284 Rat
SwissProt: Q96NW7 Human
SwissProt: Q80TE7 Mouse
SwissProt: P70587 Rat
Unigene: 479658 Human
Unigene: 132162 Mouse
Unigene: 89629 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
