Rabbit Anti-Hippocalcin/FITC Conjugated antibody

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BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-bi

Cat:

SL11348R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Hippocalcin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

22kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.

Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.

Tissue Specificity:
Brain specific.

Post-translational modifications:
Myristoylation facilitates interaction with membranes.

Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.

Database links:

Entrez Gene: 648 Human

Entrez Gene: 509772 Cow

Entrez Gene: 15444 Mouse

Entrez Gene: 29177 Rat

Omim: 142622 Human

SwissProt: Q4PL64 Cow

SwissProt: P16874 Human

SwissProt: P16875 Mouse

SwissProt: P16876 Rat

Unigene: 632391 Human

Unigene: 384452 Mouse

Unigene: 11019 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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