background:
ERCs (ERC1 and ERC2) also referred to as ELKS and CAST are related proteins which share an identical SLCterminal sequence. They interact with the conserved RIM PDZ domain via an unusual PDZ binding motif. ERC2/CAST 1 is only expressed as a single RIM binding variant. All ERCs have been shown to interact with Rab6, a protein involved in membrane trafficking at the Golgi complex. The function of these proteins has not been determined yet. They may link Rab6 mediated non-neuronal membrane traffic at the Golgi complex to neuronal membrane traffic at the active zone executed via RIMs.
Function:
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Subunit:
Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its SLCterminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A.
Subcellular Location:
Cytoplasm. Cell junction; synapse. Cell junction; synapse: synaptosome. Cytoskeleton. Note: In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density.
Database links:
Entrez Gene: 26059 Human
Entrez Gene: 238988 Mouse
Entrez Gene: 259269 Rat
SwissProt: O15083 Human
SwissProt: Q6PH08 Mouse
SwissProt: Q8K3M6 Rat
Unigene: 476389 Human
Unigene: 33604 Mouse
Unigene: 213719 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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