background:
Dynamin III is a microtubule-associated, force-producing GTPase that can form helical structures around the neck of vesicles. GTP hydrolysis-dependent extension of the helical structure releases the vesicle. Dynamin III contains a pair of phosphorylation sites at Ser 759 and Ser 763. Both 3.0 and 7.2 kb Dynamin III transcripts are detectable in brain. The 3.0 kb Dynamin III transcript is also detectable in testis. The 7.2 kb Dynamin III transcript is brain-specific for a protein thought to influence synaptogenesis in the CNS through recycling, neurotransmitter reuptake and growth factor-receptor signaling, in a thyroid hormone-dependent manner. A 6 kb antisense transcript (Dnm3os) contained within an intron of the mouse Dnm3 gene may be under transregulation by twist during mouse development. Dynamin III and Dnm3os transcripts overlap during embryogenesis and in adult tissues, except that Dynamin III is abundant in adult brain and testis whereas Dnm3os is abundant in embryos and gravid uterus.
Function:
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis.
Subcellular Location:
Cytoplasm. Cytoplasm; cytoskeleton. Microtubule-associated.
Similarity:
Belongs to the dynamin family.
Contains 1 GED domain.
Contains 1 PH domain.
Database links:
Entrez Gene: 26052 Human
Entrez Gene: 103967 Mouse
Entrez Gene: 171574 Rat
Omim: 611445 Human
SwissProt: Q9UQ16 Human
SwissProt: Q8BZ98 Mouse
SwissProt: Q08877 Rat
Unigene: 654775 Human
Unigene: 441620 Mouse
Unigene: 11191 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
