background:
BEGAIN is a 593 amino acid protein that localizes to cytoplasm and membrane. BEGAIN interacts with PSD-95 and SAPAP1 and forms a ternary complex and may sustain the structure of the postsynaptic density (PSD). BEGAIN is a novel PSD component associated with the core complex of PSD-95 and SAPAP. Because BEGAIN and SAPAP interact with the same region of PSD-95, BEGAIN and SAPAP may compete for the binding to PSD-95 and cannot interact with PSD-95 simultaneously. The SLCterminal region of BEGAIN is involved in the interaction with PSD-95 whereas the N-terminal region has a coiled-coil structure that may interact with other molecules. BEGAIN is specifically expressed in brain and enriched in the PSD fraction. BEGAIN is also expressed in neurons and enriched at synaptic junctions, and is likely involved in the organization of synaptic junction components.
Function:
Brain-enriched guanylate kinase-associated protein (BEGAIN) interacts with postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90. BEGAIN has been detected in nuclei and at synapses in neurons.
Subunit:
Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity).
Subcellular Location:
Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).
Database links:
Entrez Gene: 57596 Human
Entrez Gene: 380785 Mouse
Entrez Gene: 79146 Rat
Entrez Gene: 443287 Sheep
SwissProt: Q9BUH8 Human
SwissProt: Q68EF6 Mouse
SwissProt: O88881 Rat
SwissProt: Q6R6L0-4 Sheep
Unigene: 211751 Human
Unigene: 342085 Mouse
Unigene: 30036 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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