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Rabbit Anti-PTP zeta/FITC Conjugated antibody
background:
PTP zeta (receptor-type protein tyrosine phosphatase zeta) is a type I membrane protein chondroitin sulfate proteoglycan with a transmembrane domain and intracellular tyrosine phosphatase domains. PTP zeta may be involved in the regulation of specific developmental processes in the CNS. PTP zeta is developmentally regulated in the brain and specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. PTP zeta belongs to the protein-tyrosine phosphatase family and contains 1 eukaryotic-type carbonic anhydrase domain, 1 fibronectin type III domain and 2 tyrosine-protein phosphatase domains.
Function:
May be involved in the regulation of specific developmental processes in the CNS.
Subunit:
The carbonic-anhydrase like domain binds to contactin (By similarity).
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Tissue Specificity:
Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.
Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Contains 1 alpha-carbonic anhydrase domain.
Contains 1 fibronectin type-III domain.
Contains 2 tyrosine-protein phosphatase domains.
Database links:
Entrez Gene: 5803 Human
Entrez Gene: 19283 Mouse
Entrez Gene: 25613 Rat
Omim: 176891 Human
SwissProt: P23471 Human
SwissProt: Q62656 Rat
Unigene: 489824 Human
Unigene: 10088 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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