Rabbit Anti-PCP4/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-PCP4/FITC Conjugated antibody

Brain specific antigen PCP 4; Brain specific polypeptide PEP 19; Brain specific polypeptide PEP19; PEP19; Purkinje cell protein 4; PCP-4; PCP4_HUMAN; PEP-19.

Cat:

SL11326R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human PCP4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

7kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
PCP-4 is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the SLCterminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer’s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Function:
Probable regulator of calmodulin signaling.

Subunit:
Binds to both calcium-free and calcium activated calmodulin, affinity for calcium-bound form is 50-fold greater.

Similarity:
Belongs to the PCP4 family.
Contains 1 IQ domain.

Database links:

Entrez Gene: 5121 Human

Entrez Gene: 18546 Mouse

Entrez Gene: 25510 Rat

Omim: 601629 Human

SwissProt: P48539 Human

SwissProt: P63054 Mouse

SwissProt: P63055 Rat

Unigene: 80296 Human

Unigene: 5023 Mouse

Unigene: 9736 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall