background:
Nova-1 and Nova-2 are members of a superfamily of protein regulators of RNA metabolism in neurons. Both are nuclear RNA binding proteins with K homology motifs, conserved protein sequences which bind to RNA (1,2). Nova proteins, normally sequestered in the central nervous system, are expressed by systemic tumors in patients with the autoimmune disorder paraneoplastic opsoclonus-myoclonus ataxia (POMA) (3,4). Nova-1 is expressed in the hindbrain and ventral spinal cord and Nova-2 is expressed in the neocortex and hippocampus (4). Nova-1 is necessary for regulating neuron-specific alternative splicing of the glycine receptor Alpha2 pre-mRNA (5).
Function:
NOVA2 may regulate RNA splicing or metabolism in a specific subset of developing neurons. It binds single strand RNA.
Subunit:
Interacts with PTBP2; the interaction is direct (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Brain. Expression restricted to astrocytes.
Similarity:
Contains 3 KH domains.
Database links:
Entrez Gene: 4858 Human
Entrez Gene: 384569 Mouse
Omim: 601991 Human
SwissProt: Q9UNW9 Human
Unigene: 375439 Human
Unigene: 262724 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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