background:
Members of the postsynaptic density-95 (PSD-95)/SAP90 family of membrane-associated guanylate kinase (MAGUK) proteins function as multimodular scaffolds that organize protein-signaling complexes at neuronal synapses. SAPAP3 (PSD-95/SAP90-binding protein 3), also known as DLGAP3 (disks large-associated protein 3) or DAP3, is a 979 amino acid protein that belongs to the SAPAP family of PSD-95/SAP90-associated proteins. Localized to the cell junction, as well as to the peripheral membrane and the cell synapse, SAPAP3 is thought to play a role in the organization of neuronal cell signaling and synapses, and may also function as an adaptor protein, possibly linking ion channels with the cytoskeleton.
Function:
SAPAP3, (DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist.
Subunit:
Interacts with DLG4/PSD-95.
Subcellular Location:
Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note=Postsynaptic density of neuronal cells.
Similarity:
Belongs to the SAPAP family.
Database links:
Entrez Gene: 58512 Human
Entrez Gene: 242667 Mouse
Entrez Gene: 286923 Rat
Omim: 611413 Human
SwissProt: O95886 Human
SwissProt: Q6PFD5 Mouse
SwissProt: P97838 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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