Rabbit Anti-Neuroserpin/FITC Conjugated antibody

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Neuroserpin; NEUS_HUMAN; Peptidase inhibitor 12; PI-12; PI12; Protease inhibitor 12; Serine or cysteine proteinase inhibitor clade I (neuroserpin) member 1; Serine or cysteine proteinase inhibitor clade I member 1; Serpin I1; Serpin peptidase inhibitor cl

Cat:

SL11317R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human Neuroserpin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

45kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Neuroserpin is an axonally secreted glycoprotein in the central nervous system (CNS) that belongs to the family of protease inhibitors known as serpins (1,2). Neuroserpin is a serine-protease inhibitor (3) that forms SDS-stable complexes with tissue plasminogen activator (tPA), urokinase and plasmin, but not thrombin (2,4,5). Neuroserpin is expressed in the neocortex, the hippocampal formation, the olfactory bulb and the amygdala in the adult CNS, and it is expressed in the cerebellum, the granule cells and a subgroup of Purkinje cells in the developing embryo (2). tPA expression has been linked to "neuronal plasticity", either in the developing embryo CNS (2,4) or in cases of synpatic remodeling or long-term potentiation (6). Overexpression of tPA may promote neuronal cell death (6). Mutations in the gene which codes for neuroserpin are linked to hereditary dementia (7). Intracerebral administration of neuroserpin after stroke decreases stroke volume and diminishes the apoptotic features of the resulting ischemic penumbra (6).

Function:
Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator.

Subcellular Location:
Secreted.

Tissue Specificity:
Predominantly expressed in the brain.

DISEASE:
Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B) [MIM:604218]. FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 5274 Human

Entrez Gene: 20713 Mouse

Entrez Gene: 116459 Rat

Omim: 602445 Human

SwissProt: Q99574 Human

SwissProt: O35684 Mouse

SwissProt: Q9JLD2 Rat

Unigene: 478153 Human

Unigene: 41560 Mouse

Unigene: 52632 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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