background:
TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
Function:
Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis.
Subunit:
May interact with CASP8; however, such result is unclearsince PubMed:19079267 could not reproduce the interaction withCASP8.
Tissue Specificity:
Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin
Similarity:
Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily.
Database links:
Entrez Gene: 79626 Human
Entrez Gene: 69769 Mouse
Entrez Gene: 100328663 Rabbit
Entrez Gene: 310663 Rat
Entrez Gene: 510652 Cow
Omim: 612112 Human
SwissProt: A9X192 Baboon
SwissProt: Q3ZBK5 Cow
SwissProt: Q6P589 Human
SwissProt: Q9D8Y7 Mouse
SwissProt: B7NZC7 Rabbit
SwissProt: Q6AYJ8 Rat
Unigene: 709522 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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