background:
CRTAM, (class-I MHSLCrestricted T-cell associated molecule), is an immunoglobulin-superfamily transmembrane protein and a new member of the nectin-like (Necls) family. In the immune system, CRTAM expression has been shown to be restricted to activated class-I MHSLCrestricted T cells, including NKT and CD8 T cells. CRTAM interacts with CADM1 and promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Nectin-like (Necl) molecule 2, has been identified as a ligand of CRTAM. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system.
Function:
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Subunit:
Interacts with CADM1.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
In the immune system, expression is restricted to activated class-I MHSLCrestricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues.
Similarity:
Belongs to the nectin family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Database links:
Entrez Gene: 56253 Human
GenBank: BC070266.1 Human
Omim: 612597 Human
SwissProt: O95727 Human
Unigene: 159523 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CRTAM蛋白与调节细胞极性有关。细胞极性（cell polarity）的调控对于控制细胞的形态发生非常关键，并且这一过程在很多生物学功能中发挥着重要的作用，包括细胞分裂、分化、迁移等基础过程以及器官发生中的复杂行为等。细胞蛋白的空间结构排列是细胞极性形成的基础。抗原呈递细胞（antigen-presenting cell，APC）诱导T细胞的激活，而这会导致免疫突触（immunological synapse，IS）的形成、T细胞受体（TCR）接触信号衔接平台的组装、细胞支架的重组以及第二信使的产生等。
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