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Rabbit Anti-VEGFB167 /FITC Conjugated antibody
background:
The onset of angiogenesis is believed to be an early event in tumorigenesis and may facilitate tumor progression and metastasis. Several growth factors with angiogenic activity have been described and include fibroblast growth factor (FGF), platelet derived growth factor (PDGF) and vascular endothelial growth factors (VEGFs). The VEGF protein family is comprised of VEGF, VEGF-B, VEGF-C and VEGF-D, all of which may exhibit angiogenic function in vivo. VEGF-B, which exists as two alternatively spliced isoforms known as VEGF-B167 and VEGF-B186, is abundantly expressed in heart and skeletal muscle and is frequently co-expressed with VEGF. VEGF-C binds to and specifically activates Flt-4 and Flk-1.
Function:
Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
Subcellular Location:
Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
Tissue Specificity:
Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
Post-translational modifications:
VEGF-B167 is O-glycosylated.
Similarity:
Belongs to the PDGF/VEGF growth factor family.
Database links:
Entrez Gene: 7423 Human
Entrez Gene: 22340 Mouse
Entrez Gene: 89811 Rat
Omim: 601398 Human
SwissProt: P49765 Human
SwissProt: P49766 Mouse
SwissProt: O35485 Rat
Unigene: 78781 Human
Unigene: 15607 Mouse
Unigene: 198550 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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