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Rabbit Anti-lipocalin 1/LCN1/FITC Conjugated antibody
background:
Lipocalin-1 is a secretory protein that is highly expressed in fluids covering epithelial surfaces such as tears and respiratory secretions. This major lipid-binding protein in tears is also called tear lipocalin (TL) and von Ebner’s gland protein (VEG), as it is also a major secretion of these lingual salivary glands. In addition to lacrimal glands and lingual glands, Lipocalin-1 is secreted by nasal mucosal glands, secretory glands of the tracheobronchial tract, sweat glands, mammary glands, adrenal gland, prostate, thymus, testis and corticotrophs of the pituitary gland. Specifically, Lipocalin-1 functions to stabilize the lipid film of human tear fluid by removing harmful lipids from the human corneal surface and delivering them to the aqueous phase of tears. Lipocalin-1 may also function as a transporter of hydrophobic molecules such as bitter substances on the tongue.
Function:
Could play a role in taste reception. Could be necessary for the concentration and delivery of sapid molecules in the gustatory system. Can bind various ligands, with chemical structures ranging from lipids and retinoids to the macrocyclic antibiotic rifampicin and even to microbial siderophores. Exhibits an extremely wide ligand pocket.
Subunit:
Homodimer. Binds to LMBR1L which may mediate its endocytosis.
Subcellular Location:
Secreted.
Tissue Specificity:
Mainly expressed in lachrymal and salivary glands. Also expressed in the prostate.
Similarity:
Belongs to the calycin superfamily. Lipocalin family.
Database links:
Entrez Gene: 3933 Human
Omim: 151675 Human
SwissProt: P31025 Human
Unigene: 530311 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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