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Rabbit Anti-Fascin-3/FITC Conjugated antibody
background:
Cell adhesion to extracellular matrix is an important physiological stimulus for organization of the Actin-based cytoskeleton. Adhesion to the matrix glycoprotein Thrombospondin 1 triggers the sustained formation of F-Actin microspikes that contain the Actin-bundling protein Fascin. These structures are also implicated in cell migration, which may be an important function of Thrombospondin 1 in tissue remodelling and wound repair. Fascin bundles Actin microfilaments within dynamic cellular structures such as microspikes, stress fibers and membrane ruffles. Fascin could serve as a prognostic factor for abnormal ovarian epithelial pathology and could be a novel target for the treatment of ovarian cancer. Fascin, an Actin-bundling protein, identifies dendritic cells in the blood and in tissues.
Function:
Acts as an actin bundling protein (By similarity).
Subcellular Location:
Cytoplasm, cytoskeleton (By similarity).
Tissue Specificity:
Expressed in testis.
Similarity:
Belongs to the fascin family.
Database links:
Entrez Gene: 29999 Human
Entrez Gene: 56223 Mouse
SwissProt: Q9NQT6 Human
SwissProt: Q9QXW4 Mouse
Unigene: 712692 Human
Unigene: 31708 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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