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Rabbit Anti-ESE1/FITC Conjugated antibody
background:
ESE-1, a member of the Ets family of transcription factors, critically regulates epithelial cell differentiation and mediates vascular inflammation. ESE-1 is strongly expressed in vascular endothelium and smooth muscle cells where it is induced in response to inflammatory cytokines and lipopolysaccharides, interacts with NF-KappaB to induce nitric oxide synthase, and is induced during terminal differentiation of epidermal and primary keratinocytes. In addition, ESE-1 is upregulated upon differentiation of corneal epithelium and interacts with Sp1 and AP-1 proteins to induce squamous differentiation marker expression in bronchial epithelial cells.
Function:
Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
Subunit:
Interacts with TBP. Interacts with CREBBP and EP300; these act as transcriptional coactivators of ELF3 and positively modulate its function. Interacts with XRCC5/KU86 and XRCC6/KU70; these inhibit the ability of ELF3 to bind DNA and negatively modulate its transcriptional activity. Associated with CLND7 and POU2F3.
Subcellular Location:
Cytoplasm. Nucleus. Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism.
Tissue Specificity:
Expressed exclusively in tissues containing a high content of terminally differentiated epithelial cells including mammary gland, colon, trachea, kidney, prostate, uterus, stomach and skin.
Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
Contains 1 PNT (pointed) domain.
Database links:
Entrez Gene: 1999 Human
Entrez Gene: 13710 Mouse
Entrez Gene: 304815 Rat
Omim: 602191 Human
SwissProt: P78545 Human
SwissProt: Q3UPW2 Mouse
SwissProt: Q4V7E1 Rat
Unigene: 67928 Human
Unigene: 441439 Mouse
Unigene: 3063 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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