background:
Musclin, also designated osteocrin (Ostn), shows no homology with any known genes, except that it contains two conserved sequence motifs homologous to the natriuretic peptide family. Musclin is highly expressed in cells of osteoblast lineage and in skeletal muscle tissue, where it is tightly regulated by nutritional changes. It is secreted as either a full-length precursor protein or a processed form. A novel skeletal muscle-derived secretory factor, Musclin may play a role in bone formation and be linked to glucose metabolism. Studies indicate that insulin increases Musclin expression, whereas epinephrine, isoproterenol and forskolin reduce its expression. Musclin is expressed in osteoblasts and young osteocytes. In mouse tissues, expression is bone-specific, although minimal Musclin expression is also observed in muscle, kidney, testis and heart tissues.
Function:
Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in bone.
Database links:
Entrez Gene: 344901 Human
Entrez Gene: 239790 Mouse
Entrez Gene: 72730 Rat
Omim: 610280 Human
SwissProt: P61366 Human
SwissProt: P61364 Mouse
SwissProt: Q149W1 Mouse
SwissProt: P61365 Rat
Unigene: 526794 Human
Unigene: 390176 Mouse
Unigene: 29193 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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