Rabbit Anti-RECQL5/FITC Conjugated antibody

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ATP-dependent DNA helicase Q5; DNA helicase, RecQ like type 5; DNA helicase, RECQ-like, type 5; RecQ helicase protein-like 5 beta; RecQ protein-like 5; RecQ protein-like 5, isoform CRA_b; RecQ5; Recq5b; Recql5b; RECQ5_HUMAN.

Cat:

SL11231R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human RECQL5

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

109kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing.

Function:
May have an important role in DNA metabolism.

Subunit:
Interacts with TOP3A and TOP3B.

Subcellular Location:
Cytoplasmic and Nuclear, depending on the isoform.

Tissue Specificity:
Ubiquitous

Similarity:
Belongs to the helicase family. RecQ subfamily.
Contains 1 helicase ATP-binding domain.
Contains 1 helicase SLCterminal domain.

Database links:

Entrez Gene: 483317 Dog

Entrez Gene: 9400 Human

Entrez Gene: 287834 Rat

Omim: 603781 Human

SwissProt: O94762 Human

Unigene: 632229 Human

Unigene: 198916 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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