Rabbit Anti-Phospho-JunB (Thr102 + Thr104)/FITC Conjugated antibody

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Phospho-JunB (Thr102/Thr104); P-JunB (Phospho Thr102/Thr104); Activator protein 1; AP 1; AP1; Jun B; Jun B proto oncogene; Jun B protooncogene; JunB proto oncogene; JunB protoncogene 9; JunB protooncogene; Transcription factor jun B; Transcription factor

Cat:

SL11228R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Guinea Pig,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human JunB around the phosphorylation site of Thr102/Thr104 [TT(p-T)P(p-T)PP]

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

38kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The cJun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus vjun oncogene. JunB and JunD have been shown to be almost identical to cJun in their C terminal regions, which are involved in dimerization and DNA binding, whereas their N terminal domains, which are involved in transcriptional activation, diverge. JunB is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Function:
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'.

Subunit:
Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains).

Subcellular Location:
Nucleus.

Post-translational modifications:
Ubiquitinated by ITCH, leading to its degradation.

Similarity:
Belongs to the bZIP family. Jun subfamily.
Contains 1 bZIP (basic-leucine zipper) domain.

Database links:

Entrez Gene: 3726 Human

Entrez Gene: 16477 Mouse

Entrez Gene: 24517 Rat

Omim: 165161 Human

SwissProt: P17275 Human

SwissProt: P09450 Mouse

SwissProt: P24898 Rat

Unigene: 25292 Human

Unigene: 1167 Mouse

Unigene: 470093 Mouse

Unigene: 3166 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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