background:
Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met.
Function:
Plexin B2 is a transmembrane receptor for the class 4 semaphorin, SEMA4D. This receptor has key roles in RHOA activation and subsequent changes of the actin cytoskeleton, axon guidance, invasive growth and cell migration.
Subunit:
Monomer, and heterodimer with PLXNB1. Interacts with SEMA4C, SEMA4D and SEMA4G (By similarity). Binds MET, ARHGEF11 and ARHGEF12. May also interact with MST1R.
Subcellular Location:
Membrane; single-pass type I membrane protein.
Similarity:
Belongs to the plexin family.
Contains 3 IPT/TIG domains.
Contains 1 Sema domain.
Database links:
Entrez Gene: 23654 Human
Entrez Gene: 140570 Mouse
Entrez Gene: 315217 Rat
Omim: 604293 Human
SwissProt: O15031 Human
SwissProt: Q3UH76 Mouse
Unigene: 3989 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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