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Rabbit Anti-KLC1/FITC Conjugated antibody
background:
The kinesin family of motor proteins comprise at least two forms of conventional kinesin (kinesin-I). They are encoded by different genes and designated ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells. Conventional kinesin is a heterotetramer of two kinesin heavy chain subunits and two kinesin light chain subunits. While the kinesin heavy chain contains motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding. The motor protein kinesin is a heterotetramer composed of two heavy chains and two light chains. Kinesin motor activity is dependent on the presence of ATP and microtubules.
Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
Subunit:
Belongs to the kinesin light chain family.
Contains 6 TPR repeats.
Subcellular Location:
Cytoplasm; cytoskeleton.
Tissue Specificity:
Found in a variety of tissues. Mostly abundant in brain and spine.
Post-translational modifications:
Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.
Similarity:
Belongs to the kinesin light chain family.
Contains 6 TPR repeats.
Database links:
Entrez Gene: 3831 Human
Entrez Gene: 16593 Mouse
Entrez Gene: 171041 Rat
Omim: 600025 Human
SwissProt: Q07866 Human
SwissProt: O88447 Mouse
SwissProt: P37285 Rat
Unigene: 20107 Human
Unigene: 657678 Human
Unigene: 278357 Mouse
Unigene: 106230 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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