background:
The BTB (Broad-Complex, Tramtrack and Bric a brac) domain, also known as the POZ (POxvirus and Zinc finger) domain, is an N-terminal homodimerization domain that contains multiple copies of kelch repeats and/or C2H2-type zinc fingers. Proteins that contain BTB domains are thought to be involved in transcriptional regulation via control of chromatin structure and function. KCTD12 (potassium channel tetramerisation domain containing 12), also known as PFET1 or PFETIN, is a 325 amino acid protein that is expressed in fetal organs, with highest levels in the cochlea and brain and extremely low levels in adult organs, such as brain and lung. KCTD12 is considered a prognostic biomarker of gastrointestinal stromal tumors.
Function:
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Subcellular Location:
Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > postsynaptic cell membrane.
Tissue Specificity:
Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Database links:
UniProtKB/Swiss-Prot: Q96CX2.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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