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Rabbit Anti-Alpha s1 Casein/FITC Conjugated antibody
background:
alpha-S1-casein, also known as CSN1S1, CSN1 or CASA, is a 185 amino acid secreted protein that is mammary gland-specific and belongs to the alpha-casein family. Existing as a disulfide-linked heterodimer with ⅹ-casein, alpha-S1-casein plays an important role in the ability of milk to transport calcium phosphate, a family of minerals that are key components of bone and teeth. alpha-S1-casein exists as multiple alternatively spliced isoforms and is encoded by a gene which maps to a region on human chromosome 4 that encodes other casein family members. Chromosome 4 houses nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Important role in the capacity of milk to transport calcium phosphate.
Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.
Subcellular Location:
Secreted.
Tissue Specificity:
Mammary gland specific. Secreted in milk.
Similarity:
Belongs to the alpha-casein family.
Database links:
Entrez Gene: 282208 Bovin
Entrez Gene: 1446 Human
Omim: 115450 Human
SwissProt: P47710 Human
SwissProt: P02662 Bovin
Unigene: 3155 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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