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Rabbit Anti-delta 1 Catenin/FITC Conjugated antibody
background:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both SLC and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 SLCterminal cleavage.
Function:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both SLC and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 SLCterminal cleavage.
Subunit:
Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
Subcellular Location:
Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm.
Tissue Specificity:
Expressed in vascular endothelium.
Post-translational modifications:
Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ.
Similarity:
Belongs to the beta-catenin family.
Contains 10 ARM repeats.
Database links:
Entrez Gene: 300 Human
Entrez Gene: 12388 Mouse
Entrez Gene: 311163 Rat
Omim: 601045 Human
SwissProt: O60716 Human
SwissProt: P30999 Mouse
Unigene: 166011 Human
Unigene: 35738 Mouse
Unigene: 9435 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
p120-连环素也可能参与细胞侵入力调节.
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