background:
KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies.
Function:
Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC.
Subunit:
Interacts with IGFN1 and FLNC.
Subcellular Location:
Cytoplasm
Tissue Specificity:
Specifically expressed in skeletal and cardiac muscle.
Similarity:
Belongs to the transglutaminase-like superfamily.
Database links:
Entrez Gene: 339855 Human
Entrez Gene: 16716 Mouse
Omim: 605739 Human
SwissProt: Q8NSH2 Human
SwissProt: Q8C8H8 Mouse
Unigene: 146730 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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