background:
Neurexophilin family (Neurexophilin-1-4) of neuropeptide-like glycoproteins that are proteolytically processed after synthesis. Neurexophilin-1-3 are secreted proteins that are thought to function as signaling molecules which specifically bind to target proteins, such as neurexin I?(a protein that promotes adhesion between dendrites and axons), and are essential for proper neurotransmitter release. While Neurexophilin-1 is located primarily in spleen tissue, Neurexophilin-2 is expressed primarily in kidney and both Neurexophilin-2 and Neurexophilin-3 are highly expressed in brain. Defects in the gene encoding Neurexophilin-1 may be associated with schizophrenia, a mental disorder characterized by an abnormal perception of reality.
Function:
May be signaling molecules that resemble neuropeptides and that act by binding to alpha-neurexins and possibly other receptors.
Subunit:
Belongs to the neurexophilin family.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in brain and kidney.
Post-translational modifications:
May be proteolytically processed at the boundary between the N-terminal non-conserved and the central conserved domain in neuron-like cells (By similarity).
Similarity:
Belongs to the neurexophilin family.
Database links:
UniProtKB/Swiss-Prot: O95156.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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