background:
Sidekick-2 (SDK2), also known as KIAA1514, is a 2,172 amino acid single-pass type I membrane protein containing thirteen fibronectin type-III domains and six Ig-like C2-type (immunoglobulin-like) domains. Acting as a cell adhesion protein, Sidekick-2 guides axonal terminals to synapses in developing neurons. Sidekick-2 may require the interaction with MAGI scaffolding proteins for proper localization and function. Existing as four alternatively spliced isoforms, the gene encoding Sidekick-2 maps to human chromosome 17q25.1. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth have been linked to chromosome 17. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
Function:
Sidekick 2 is a cell adhesion protein that guides axonal terminals to specific synapses in developing neurons.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
Similarity:
Contains 13 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
UniProtKB/Swiss-Prot: Q58EX2.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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