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Rabbit Anti-MPO/FITC Conjugated antibody
background:
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008].
Function:
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Subunit:
Tetramer of two light chains and two heavy chains.
Subcellular Location:
Lysosome.
DISEASE:
Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:25920]. MPD is an autosomal recessive defect that results in disseminated candidiasis.
Similarity:
Belongs to the peroxidase family. XPO subfamily.
Database links:
Entrez Gene: 4353 Human
Entrez Gene: 17523 Mouse
Entrez Gene: 303413 Rat
Omim: 606989 Human
SwissProt: P05164 Human
SwissProt: P11247 Mouse
Unigene: 458272 Human
Unigene: 4668 Mouse
Unigene: 47782 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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