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Rabbit Anti-PCDHGA10/FITC Conjugated antibody
background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHGA10 (Protocadherin gamma-A10) is a 936 amino acid that is one of 22 proteins encoded by the protocadherin gamma cluster. The protocadherein gamma cluster consists of three subfamilies (A, B and C) and PCDHGA10 is a member of the gamma subfamily A. PCDHGA10 is a type I transmembrane receptor containing six cadherin motifs and is expressed in the central nervous system where it localizes to synapses. Members of the gamma cluster of protocadherins are essential for neuronal survival. There are two isoforms of PCDHGA10 that are produced as a result of alternative splicing events.
Function:
Potential calcium dependent cell adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Subcellular Location:
Cell membrane; Single pass type I membrane protein.
Similarity:
Contains 6 cadherin domains.
Database links:
Entrez Gene: 56106 Human
Omim: 606297 Human
SwissProt: Q9Y5H3 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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