background:
Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA3 (Protocadherin alpha-3) is a 950 amino acid single-pass transmembrane protein that contains six cadherin domains. PCDHA3 is a unique cadherin in that it likely functions in spermatogenesis and may also have a role in organizing germ cell-specific structures, such as the flagellum, acrosome and intercellular bridge. There are two isoforms of PCDHA13 that are produced as a result of alternative splicing events.
Function:
PCDHA3 contains six cadherin domains. It is thought to be a calcium dependent cell adhesion protein and may be involved in the establishment and maintenance of specific neuronal connections in the brain. There are two named isoforms.
Subcellular Location:
Cell membrane; Single pass type I membrane protein.
Similarity:
Contains 6 cadherin domains.
Database links:
Entrez Gene: 56145 Human
Entrez Gene: 192163 Mouse
Entrez Gene: 116780 Rat
Omim: 606309 Human
SwissProt: Q9Y5H8 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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