Rabbit Anti-SLC40A1/FITC Conjugated antibody

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Ferroportin 1; Ferroportin-1; FPN1; HFE4; IREG1; Iron regulated transporter 1; Iron-regulated transporter 1; MTP1; S40A1_HUMAN; SLC40A1; Solute carrier family 40 member 1; MST079; MSTP079; MTP1; SLC11A3.

Cat:

SL4906R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human SLC40A1/FPN1 (365-405aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

63kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
SLC40A1 may be involved in iron export from duodenal epithelial cells and also in transfer of iron between maternal and fetal circulation. It mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin). Defects in SLC40A1 are the cause of hemochromatosis type 4, an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin.

Function:
May be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase (hephaestin and/or ceruloplasmin).

Subunit:
Belongs to the S1LC40A transporter family.

Subcellular Location:
Cell membrane. Localized to the basolateral membrane of polarized epithelial cells.

Tissue Specificity:
Expressed in placenta, intestine, muscle and spleen.

DISEASE:
Defects in SLC40A1 are the cause of hemochromatosis type 4 (HFE4) [MIM:606069]. HFE4 is an autosomal dominant iron-loading disorder characterized by early iron accumulation in reticuloendothelial cells and a marked increase in serum ferritin before elevation of the transferrin saturation.

Similarity:
Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.

Database links:

Entrez Gene: 30061 Human

Entrez Gene: 53945 Mouse

Entrez Gene: 170168 Rat

Omim: 604653 Human

SwissProt: Q9NP59 Human

SwissProt: Q9JHI9 Mouse

SwissProt: Q923U9 Rat

Unigene: 643005 Human

Unigene: 28756 Mouse

Unigene: 15324 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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