Rabbit Anti-PCDH1/FITC Conjugated antibody

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Cadherin like 1; Cadherin like protein 1; PC 42; PC42; PCDH 1; PCDH-1; PCDH 42; PCDH42; Protocadherin 1; Protocadherin 42; Protocadherin1; Protocadherin42.

Cat:

SL11111R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PCDH1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

110kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Protocadherins are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-to-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH1 is a 1,026 amino acid single-pass type I membrane protein that contains seven cadherin domains and is a member of the protocadherin family. Localized to cell-cell and cell-matrix boundaries and expressed at high levels in brain and neuro-glial cells, PCDH1 is thought to be involved in cell adhesion and cell-cell interactions and may play a role in neuronal development. PCDH1 contains a SLCterminal cytoplasmic region, an extracellular region and a transmembrane region, and is expressed as two isoforms due to alternative splicing events.

Function:
PCDH1 (Protocadherin 1) belongs to the protocadherin family, a subfamily of the cadherin superfamily. It is a membrane protein found at cell-cell boundaries suggesting a role in cell-cell interaction processes. It is involved in neural cell adhesion, suggesting a possible role in neuronal development.

Subcellular Location:
Cell junction. Cell membrane. Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.

Tissue Specificity:
Highly expressed in the brain and neuro-glial cells.

Similarity:
Contains 7 cadherin domains.

Database links:

Entrez Gene: 5097 Human

Omim: 603626 Human

SwissProt: Q08174 Human

Unigene: 79769 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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