background:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin-1, which is the mammalian homolog of UNSLC6 from C. elegans, is largely expressed in the developing nervous system and in mesodermal tissues. Netrin-1 is expressed by the floor plate as either a cell associated protein or in a diffusible form, and it binds to several surface receptor components, including deleted in colorectal cancer (DCC) and neogenin. During embryonic development, netrin-1 diffuses through the neuronal epithelium, where it forms a chemoattractant gradient that directs axonal migration to the ventral midline of the spinal cord. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient.
Function:
Promotes neurite outgrowth of both axons and dendrites.
Subunit:
Interacts with LRRC4 (By similarity).
Subcellular Location:
Cell membrane.
Post-translational modifications:
N-glycosylated (By similarity).
Similarity:
Contains 3 laminin EGF-like domains.
Contains 1 laminin N-terminal domain.
Database links:
Entrez Gene: 84628 Human
Entrez Gene: 171171 Mouse
Entrez Gene: 311836 Rat
SwissProt: Q96CW9 Human
SwissProt: Q8R4F1 Mouse
Unigene: 163642 Human
Unigene: 442448 Mouse
Unigene: 218540 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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