Rabbit Anti-NLGN4X/FITC Conjugated antibody

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X-linked; HNLX; KIAA1260; Neuroligin X; Neuroligin-4; NLGN4; NLGN 4; NLGN4X; Neuroligin 4 X linked; Neuroligin 4; Neuroligin X; NLGN; NLGN-4; NLGN4X; NLGN4Y; NLGNX_HUMAN.

Cat:

SL11099R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,Zebrafish,Chimpanzee,)

Immunogen：

KLH conjugated synthetic peptide derived from human NLGN4X

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

92kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs, large (Drosophila) homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].

Function:
Putative neuronal cell surface protein involved in cell-cell-interactions.

Subunit:
Belongs to the type-B carboxylesterase/lipase family.

Subcellular Location:
Membrane.

Tissue Specificity:
Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.

DISEASE:
Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism.

Similarity:
Belongs to the type-B carboxylesterase/lipase family.

Database links:

Entrez Gene: 57502 Human

Omim: 300427 Human

SwissProt: Q8N0W4 Human

Unigene: 21107 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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