background:
LSAMP is a neuronal surface glycoprotein found in cortical and subcortical regions of the limbic system expressed on the surface of somata and proximal dendrites of neurons. It is a member of the immunoglobulin (Ig) superfamily and belongs to the IgLON subfamily of cell adhesion molecules. LSAMP contains three Ig domains and a glycosylphosphatidylinositol anchor. It is a highly conserved protein between rodents and humans (99% sequence identity) and it is involved in the regulation of neurite outgrowth and mediation of proper circuit formation of limbic pathways. This suggests that LSAMP plays an important role in the development and function of the limbic system. In addition, LSAMP may function as a tumor suppressor in renal carcinomas.
Function:
Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed on limbic neurons and fiber tracts as well as in single layers of the superior colliculus, spinal chord and cerebellum.
Similarity:
Belongs to the immunoglobulin superfamily. IgLON family.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 395687 Chicken
Entrez Gene: 4045 Human
Entrez Gene: 268890 Mouse
Entrez Gene: 29561 Rat
Omim: 603241 Human
SwissProt: Q98919 Chicken
SwissProt: Q13449 Human
SwissProt: Q8BLK3 Mouse
SwissProt: Q62813 Rat
Unigene: 21289 Human
Unigene: 723683 Human
Unigene: 310524 Mouse
Unigene: 396168 Mouse
Unigene: 473653 Mouse
Unigene: 10176 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
