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Home > Product > Antibody > Rabbit Anti-LRFN3/FITC Conjugated antibody
SALM4; Fibronectin type II immunoglobulin and leucine rich repeat domains 1; Fibronectin type II, immunoglobulin and leucine rich repeat domains 1; FIGLER1; Leucine rich repeat and fibronectin type III domain containing 3; Leucine-rich repeat and fibronec
Cat:
SL11088R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Pig,Cow,Horse,Sheep,)
Immunogen：
KLH conjugated synthetic peptide derived from human LRFN3/SALM4
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
65kDa
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Unit:
Price: $
Product PDFs
Datasheet:


background:
LRFN3 is a 628 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing seven LRR (leucine-rich) repeats, LRFN3 also contains one fibronectin type-III domain, one Ig-like (immunoglobulin-like) domain, one LRRCT domain and one LRRNT domain. As a cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca2+-independent manner, LRFN3 promotes neurite outgrowth in hippocampal neurons. LRFN3 forms homomeric complexes across cell junctions (between adjacent cells), and can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. The gene that encodes LRFN3 consists of more than 8,000 bases and maps to human chromosome 19q13.12.

Function:
Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons.

Subunit:
Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4 (By similarity).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity).

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the LRFN family.
Contains 1 fibronectin type-III domain.
Contains 1 Ig-like (immunoglobulin-like) domain.
Contains 7 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 79414 Human

Entrez Gene: 233067 Mouse

Entrez Gene: 308495 Rat

Omim: 62569 Human

SwissProt: Q9BTN0 Human

SwissProt: Q8BLY3 Mouse

SwissProt: B0BNK7 Rat

Unigene: 143792 Human

Unigene: 23157 Mouse

Unigene: 50030 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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