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Rabbit Anti-TREM1/FITC Conjugated antibody
background:
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
Function:
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity).
Subunit:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Subcellular Location:
Secreted and Cell membrane.
Similarity:
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Database links:
Entrez Gene: 54210 Human
Entrez Gene: 58217 Mouse
Entrez Gene: 301229 Rat
Omim: 605085 Human
SwissProt: Q9NP99 Human
SwissProt: Q9JKE2 Mouse
Unigene: 283022 Human
Unigene: 248352 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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