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Rabbit Anti-EVA1/FITC Conjugated antibody
background:
Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial SLVlike antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic SLVtype domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Mediates homophilic cell-cell adhesion.
Subcellular Location:
Cell Membrane; Single-pass type I membrane protein, cytoskeleton
Tissue Specificity:
Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.
Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Database links:
Entrez Gene: 10205 Human
Omim: 604873 Human
SwissProt: O60487 Human
Unigene: 116651 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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