background:
Bestrophin-4 is a 473 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (Arg-Phe-Pro) motif and they function as anion channels. Bestrophin-4 acts as a calcium-sensitive chloride channel located in the cell membrane. It is believed that Bestrophin-4 also acts as a channel for other physiologically significant anions, such as bicarbonate. Bestrophin-4 is predominantly expressed in the colon, but can be found at low levels in testis, placenta, trachea, spinal chord, lung and retina.
Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta.
Similarity:
Belongs to the bestrophin family.
Database links:
Entrez Gene: 510542 Cow
Entrez Gene: 482521 Dog
Entrez Gene: 100052813 Horse
Entrez Gene: 266675 Human
Entrez Gene: 100345949 Rabbit
Entrez Gene: 689103 Rat
Omim: 607336 Human
SwissProt: Q8NFU0 Human
Unigene: 302513 Human
Unigene: 84672 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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