Rabbit Anti-Bestrophin 3/FITC Conjugated antibody

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Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3; BEST3_HUMAN; Bestrophin-3; Bestrophin3; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3.

Cat:

SL11042R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human Bestrophin 3 (45-92aa)

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

76kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Bestrophin-3 is a 668 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (arg-phe-pro) motif and they function as anion channels. Expressed predominantly in skeletal muscle but also found in spinal cord, brain, testis, thymus, retina and bone marrow, Bestrophin-3 forms calcium-sensitive chloride channels. In addition, Bestrophin-3 contains an AI (auto-inhibitory) domain that is capable of regulating the anion channel activity. Due to alternative splicing events, three isoforms exist for Bestrophin-3.

Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina.

Similarity:
Belongs to the bestrophin family.

Database links:
UniProtKB/Swiss-Prot: Q8N1M1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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