background:
The Thrombospondin proteins, Thrombospondins 1-4 and Thrombospondin 5 (also designated COMP), compose a family of glycoproteins that are involved in cell-to-cell and cell-to-matrix signaling. These extracellular, cell-surface proteins form complexes of both homo- and heteromultimers. Spondin-2, or Mindin, is also designated DIL-1 for its differential expression in cancerous and non-cancerous lung cells. Full-length SPON2 cDNA encodes a 331 amino acid protein with a domain arrangement similar to zebrafish F-Spondin and Mindin-1/Mindin-2: an FS1 domain, an FS2 domain, a hydrophobic signal sequence in the N-terminus and a Thrombospondin type I repeat. Immunoblot analysis demonstrates expression of dimers and oligomers in a concentration-dependent manner under nonreducing conditions.
Function:
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
Subunit:
Monomer. Interacts with integrin.
Subcellular Location:
Secreted; extracellular space; extracellular matrix.
Tissue Specificity:
Expressed in normal lung tissue but not in lung carcinoma cell lines.
Similarity:
Contains 1 spondin domain.
Contains 1 TSP type-1 domain.
Database links:
Entrez Gene: 10417 Human
Entrez Gene: 100689 Mouse
Entrez Gene: 171569 Rat
Omim: 605918 Human
SwissProt: Q9BUD6 Human
SwissProt: Q8BMS2 Mouse
SwissProt: Q9WV75 Rat
Unigene: 302963 Human
Unigene: 635350 Human
Unigene: 34694 Mouse
Unigene: 6699 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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