background:
Slac2-c is a Rab effector protein that is expressed in a variety of tissues including brain, heart, skin and liver. Found in the basal microvilli of retinal pigment cells and in pre- and post-synaptic areas in photoreceptor cells , Slac2-c is involved in melanosome transport and functions to link Rab 27a with the actin-based motor proteins Myosin Va and Myosin VIIa. Once linked, the Myosins are able to transport Rab 27a to retinal melanosomes, thereby linking the actin cytoskeleton with the melanosome membrane. Slac2-c contains one FYVE-type zinc finger and one Rab-binding domain and is able to bind actin-like proteins through its conserved SLCterminal region. Additionally, Slac2-c is thought to regulate the final steps of insulin exocytosis by mediating the interaction of secretory granules with the cortical actin cytoskeleton.
Function:
Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments.
Subunit:
Binds MYO5A, MYO7A and F-actin. Binds RAB27A that has been activated by GTP-binding via its N-terminus. Interacts with PRKAR2A. Interacts with components of the exocyst complex, including EXOC3 and EXOC4.
Subcellular Location:
Cytoplasm. In pre- and post-synaptic areas in photoreceptor cells and in the basal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments.
Tissue Specificity:
Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle and testis.
Similarity:
Contains 1 FYVE-type zinc finger.
Contains 1 RabBD (Rab-binding) domain.
Database links:
Entrez Gene: 25924 Human
Entrez Gene: 245049 Mouse
Entrez Gene: 72034 Rat
Omim: 611790 Human
SwissProt: Q8NFW9 Human
SwissProt: Q8K3I4 Mouse
SwissProt: Q7TNY7 Rat
Unigene: 594535 Human
Unigene: 100936 Mouse
Unigene: 161974 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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