Home
>
Product
>
Antibody
>
Rabbit Anti-TANC1/FITC Conjugated antibody
background:
TANC (tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein), also known as TANC1, is a 1,861 amino acid postsynaptic cell membrane protein that contains eleven ANK repeats, three TPR repeats and belongs to the TANC family. Considered a scaffolding component in the postsynaptic density, TANC interacts with TNIK, SAPAP1, Alpha-internexin, CaMKII, NMDA 2 and GluR-1. It is also thought that TANC interacts directly with SAP 97, PSD-95 and Homer. Upon stimulation by Rap 2, MINK1 and TNIK may phosphorylate TANC. The TANC gene encodes two alternatively spliced isoforms, contains approximately 264,025 bases and maps to human chromosome 2q24.2. Making up approximately 8% of the human genome, chromosome 2 consists of 237 million bases and encodes over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
May be a scaffold component in the postsynaptic density.
Subunit:
Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK. Interacts with MINK1.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Post-translational modifications:
Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
Similarity:
Belongs to the TANC family.
Contains 11 ANK repeats.
Contains 3 TPR repeats.
Database links:
Entrez Gene: 85461 Human
Omim: 611397 Human
SwissProt: Q9C0D5 Human
Unigene: 61590 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|
